Mechanism of Neutrophil Recruitment to the Lung After Pulmonary Contusion
نویسندگان
چکیده
منابع مشابه
Opening Up to Lung Recruitment Pulmonary Contusion and Derecruitment - The Role of Inflammation
Purpose of review: It was recently reported that a lung protective ventilation strategy resulted in no fatalities in 17 patients with ARDS secondary to lung contusion. Although the efficacy of a lung protective ventilation strategy to reduce mortality in ARDS patients has been demonstrated, the underlying mechanisms for this reduction remain unclear. Recent findings: ARDS is characterized by an...
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Transmigration of neutrophils through the microvascular endothelium is a cardinal event of acute inflammation. It has been suggested that gap junctions made of connexin43 (Cx43) may serve as a conducting pathway to spread inflammatory signals within the lung capillary network. To determine whether Cx43 contributes to neutrophil transmigration in vivo, the number of transmigrated neutrophils was...
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Treatment of pulmonary contusion when adequately established is very simple in most cases. Pathophysiological changes occur as a result of the effects produced by loss of chest wall integrity, accumulation of fluid in the pleural cavity, obstruction of the airways and lung dysfunction. The alveolar recruitment maneuver is the reopening of collapsed lung areas by increasing inspiratory pressure ...
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Lee J. Quinton, Steve Nelson, Ping Zhang, Darren M. Boé, Kyle I. Happel, Weihong Pan, and Gregory J. Bagby Department of Physiology, Department of Medicine, Section of Pulmonary Critical Care Medicine, and the Alcohol Research Center, Louisiana State University Health Sciences Center and Department of Medicine, Tulane University School of Medicine and the Veterans Affairs Medical Center, New Or...
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Regulation of iron homeostasis and the inflammatory response are tightly linked to protect the host from infection. Here we investigate how imbalanced systemic iron homeostasis in a murine disease model of hereditary hemochromatosis (Hfe(-/-) mice) affects the inflammatory responses of the lung. We induced acute pulmonary inflammation in Hfe(-/-) and wild-type mice by intratracheal instillation...
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ژورنال
عنوان ژورنال: Shock
سال: 2011
ISSN: 1073-2322
DOI: 10.1097/shk.0b013e3182144a50